Medifocus Guidebook on Peripheral Neuropathy

What is Peripheral Neuropathy?
The nervous system controls the smooth functioning of all systems in the body as well as all interactions between the human being and the environment. The nervous system is comprised of millions of neurons that are interconnected and form a communications network within the body that governs many vital functions including:

• The five senses (sight, hearing, touch, smell, and taste)
• Voluntary functions (e.g. walking, holding an object)
• Involuntary functions (e.g. breathing, blood pressure)
• Cognitive reasoning

The human nervous system has two major components:

• Central nervous system - includes the brain and spinal cord
• Peripheral nervous system - includes the nerves that lead from the brain and spinal cord to all parts of the body. An extensive system of specialized nerves makes up the peripheral nervous system which is responsible for a variety of important functions. These specialized nerves include:
  
  • motor nerves which carry messages from the brain to the body and are responsible for the ability to move any part of the body (e.g., hands, feet)
  • sensory nerves which carry information from organs to the central nervous system where it is processed into sensation (e.g., touch, temperature changes, and vibrations)
  • nerves that control autonomic (involuntary) functions including heart rate, blood pressure, breathing, digestion, and bladder function

Peripheral neuropathy is a term used to describe damage to nerves of the peripheral nervous system which leads to symptoms such as pain, numbness, tingling, burning, and weakness most commonly affecting the hands and feet. Peripheral neuropathy can be caused by a variety of precipitating factors including trauma, infection, diabetes, alcohol abuse, and cancer chemotherapy.
The incidence of peripheral neuropathy is not known with any degree of certainty. It has been estimated that approximately 2 to 3 million Americans have some form of peripheral neuropathy. The prevalence of peripheral neuropathy worldwide has been estimated to range from 2% to 8% of the population. Peripheral neuropathy affects both genders at all ages but symptoms are unique to each individual in terms of frequency, quality, and severity of pain. Idiopathic peripheral neuropathy typically affects adults over the age of 50. Peripheral neuropathy can significantly impact an individual's quality of life and daily activities by causing major disruptions including:

• Sleep disturbances
• Mood changes
• Impairment of social, occupational, and recreational functioning

Knowledge is Critical when Dealing with a Life-Altering Condition such as Peripheral Neuropathy
If you or a loved one has been diagnosed with peripheral neuropathy, it's critical to learn everything you possibly can about this condition so that you can make informed decisions about your treatment. That's why we created the Medifocus Guidebook on Peripheral Neuropathy, a comprehensive 187 page patient Guidebook that contains vital information about peripheral neuropathy that you won't find anywhere in a single source.
The Medifocus Guidebook on Peripheral Neuropathy starts out with a detailed overview of the condition and quickly imparts fundamentally important information about peripheral neuropathy, including:

• The underlying causes and risk factors for developing peripheral neuropathy, which include:
  
  • Diabetes
  • Autoimmune disorders
  • Metabolic disorders
  • Hereditary disorders
  • Infectious diseases
  • Alcohol abuse
  • Trauma
  • Cancer chemotherapy
• The different types of peripheral neuropathy that can occur based on the pattern of nerve involvement and the distribution of pain, which include:
  
  • Mononeuropathy
  • Mononeuropathy multiplex
  • Polyneuropathy
• The signs and symptoms associated with peripheral neuropathy based on the specific underlying cause, when known.
• How peripheral neuropathy is diagnosed based on a variety of factors and diagnostic tests including:
  
  • Signs and symptoms
  • Patient history and physical examination
  • Pattern of distribution of pain along sensory or motor nerves
  • Special electrodiagnostic studies, such as nerve conduction tests and electromyography (a test which measures the response of muscles to electrical stimulation)

Understanding the Standard Treatments...and the Treatment Options
The primary goals of treatment for peripheral neuropathy include accomplishing the following objectives:

• Determining and treating the underlying cause of the condition, if possible.
• Controlling and alleviating pain and other bothersome symptoms associated with the condition.
• Preserving function of the affected limbs, such as the hands and/or feet.
• Preventing a significant decrease in the patient's quality of life.

An important aspect for successfully achieving these goals is understanding the treatments - and the treatment options - for peripheral neuropathy. As you read through the section of the Guidebook that focuses on the treatment of peripheral neuropathy, you will specifically learn about:

• The management of peripheral neuropathy in patients where the underlying cause can be identified, such as diabetes, autoimmune disorders, infectious diseases, nerve compression, and cancer chemotherapy.
• The major types of medications that are often prescribed to relieve pain associated with peripheral neuropathy, which include:
  
  • Antidepressants
  • Anticonvulsants
  • Selective serotonin reuptake inhibitors
  • Narcotic analgesics
  • Topical agents such as capsaicin and lidocaine patches
• The treatment options that are available for controlling pain that does not adequately respond to drug therapy, including nerve blocks with local anesthetics and spinal cord stimulation.
• The role of physical and occupational therapy in functional rehabilitation of patients with peripheral neuropathy.
• The role of complementary and alternative therapies in the management of peripheral neuropathy.
• The impact of peripheral neuropathy on the patient's psychological well-being and quality of life, including aspects such as:
  
  • Anxiety and depression
  • Social relationships
  • Activities of daily living
  • Employment issues
  • Sleep disturbances
  • Recreational activities
  • Feelings of self-worth
• Practical tips and suggestions for how to minimize the negative impact of peripheral neuropathy on your quality of life and learn how to better cope with the condition.
• Important questions to ask your doctor about peripheral neuropathy.

A "One-of-a-Kind" Reference Guidebook on Peripheral Neuropathy that Goes Way Beyond the Fundamentals
Since 1996, when Medifocus was founded, we've learned that many people with Peripheral Neuropathy are seeking more specific information that goes beyond the fundamentals, such as the causes, diagnosis, standard treatments, and treatment options. That's why we developed a "one-of-a-kind" reference Guidebook that goes way beyond the basics and also includes the following sections:

• A Guide to Recent Medical Literature on Peripheral Neuropathy - This section of the Guidebook contains an extensive bibliography of over 100 references to recently published articles about Peripheral Neuropathy in authoritative, peer-reviewed medical journals with links to the absracts (summaries) of the articles. These articles represent the latest advances in the field and focus on cutting-edge research, new developments, and the lessons learned from recently published clinical trials involving patients with Peripheral Neuropathy. This is the same level of that is used by doctors who treat people with Peripheral Neuropathy to keep abreast of the latest developments and breakthroughs in this specialized field of medicine.
• Centers of Research for Peripheral Neuropathy - We've compiled a unique directory of doctors, hospitals, medical centers, and research institutions with special interest and, in many cases, clinical expertise in managing people with Peripheral Neuropathy. The "Centers of Research" directory is a valuable resource for quickly identifying and locating leading medical authorities and medical institutions both within the United States and other countries who are considered to be at the forefront in clinical research and treatment of Peripheral Neuropathy. You'd have to spend days - or even weeks - attempting to compile your own list of doctors and medical centers but, with the "Centers of Research" directory, the information is already right at your fingertips. All you have to do is act on the information by selecting and contacting the experts or medical institutions listed in the directory by state and country.
• Organizations and Support Groups for Peripheral Neuropathy - The Guidebook also includes a directory of organizations and support groups whose goal is to help people with Peripheral Neuropathy by providing access to information, resources, and services. Many of these organizations can answer your specific questions, enable you to "network" with other patients, and provide guidance in areas such as financial, social, or medical-legal issues. This valuable directory of organizations and support groups includes complete contact information, including phone numbers and E-mail addresses.

The Guidebook is a Value-Added Proposition that Comes with a Risk-Free Satisfaction Guarantee so that...You have Nothing to Lose and Everything to Gain
Still not sure if you'll benefit from the Medifocus Guidebook on Peripheral Neuropathy? Still not convinced that the information included in the Guidebook is worth the minimal cost? If that's the case, then please consider the following value-added proposition that comes standard with your purchase of the Guidebook:

• Free Updates for One Year - With your initial purchase of the Guidebook, you also receive access to free updates for one-full year. The Guidebook is updated with new information every 4 to 6 months, so that you will be able to access the updated information several times during the course of a year for up to one full year after the date of your initial purchase.
• Free Digest E-Mail Alerts - When you purchase the Guidebook, you will also automatically receive a free subscription to our monthly newsletter - the Medifocus Digest Alert for Peripheral Neuropathy. This is an expertly selected listing of the latest articles published in the medical literature about Peripheral Neuropathy with convenient links to the abstracts of the articles that focus on cutting-edge research, clinical trials, and the latest treatment advances. The Medifocus Digest Alert for Peripheral Neuropathy is automatically delivered straight to your "inbox" monthly and is a valuable resource for keeping up with the latest developments in Peripheral Neuropathy almost as soon as the new information is published in the medical literature.
• 10% Discount - For a limited time, you can purchase the Medifocus Guidebook on Peripheral Neuropathy at a special 10% discount off the regular list price. Your 10% discount will automatically be applied when you go to "Checkout".
• Risk-Free Satisfaction Guarantee - Your purchase comes with our RISK-FREE satisfaction guarantee. If, for whatever reason, you are not totally satisfied with the content of your Guidebook, simply contact us within 30-days of your purchase for a prompt, full refund. We are so confident that you will be satisfied with your Guidebook that we offer this RISK-FREE satisfaction guarantee unconditionally - no questions and no hassles

Doctor Says Surgery May Relieve Pain Of Neuropathy

DENVER -- Millions of Americans suffer from neuropathy, a painful condition that affects legs and feet. For many, medication is the only relief, but that can stop working.
Now a doctor in Colorado is one of just a few surgeons in the country offering another alternative.Gregory Garland says he has a tremendous amount of pain in his foot and leg and is going under the knife to treat it."I'm having the tunnels opened up around the nerves in my feet," Garland said.Dr. James Anderson of the Poudre Valley Foot and Ankle Clinic is one a very few surgeons doing a new controversial procedure for people who suffer from neuropathy."Neuropathy is basically a malfunction of nerves. You'll get burning, tingling and numbness. The pain is not sometimes bad in the beginning but it can become very severe," Anderson said.Neuropathy is common in diabetics and is the leading cause for amputations. Until now, there was little that could be done for patients.This new surgery is similar to that commonly done for carpal tunnel syndrome in the wrist."It's a decompression surgery," Anderson said.The tight areas are opened in up in the ankle, giving the nerves more room to pass."If you can release pressure from the nerves, the neuropathy symptoms can go away," Anderson said. "It's like restoring the nerves, basically."Before surgery is considered, the patient undergoes numerous tests. Surgery is not for everyone and recovery can take several months.But many patients are getting permanent relief.Dick O'Grady had the surgery 10 months ago. Before that, his life basically came to a standstill, he said."The pain became so intense that I went into the emergency room and was in the hospital for four days," he said.Now, he can do the things he loves such as working in his yard without pain. "I really feel like a success story," O'Grady said. "To this day I have absolutely no regrets. I am getting my life back and becoming more mobile. I am sleeping at night now without the pain.""We are right at about 85 percent success rate," Anderson said.Currently, the prevailing theory is there is no cure for neuropathy and some doctors adamantly discourage patients from having this surgery. It's important to discuss all the options with your own doctor.If you would like more information on the decompression surgery for neuropathy call (800) 866-4620 or go to .

Nitrogesic

Nitrogesic Descriptions

Many people are suffering from anal fissure, which is a crack or tear in the skin of the anal canal. However, anal fissures may cause painful bowel movements and bleeding as well. There may be blood on the outside of the stool or in the toilet following a bowel movement. Hence proper hygienic measures should be taken with the usage of the best medicine. Nitrogesic ointment is widely used to treat anal fissures.

Glyceryl trinitrate belongs to the class of muscle relaxants. It is an organic nitrate that donates nitric oxide. Nitroglycerin relaxes the anal sphincter muscle and provides immediate symptomatic relief in pain and spasm. To avoid surgery Nitroglycerin ointment is an ideal treatment for anal fissure. It is also used to treat hemorrhoids.

Before applying the Nitroglycerin ointment i.e. Glyceryl trinitrate ointment, please ask your doctor or for a copy of the manufacturer’s information for the patient and read it carefully. Talk to your doctor about the risks of applying Nitrogesic ointment. Do not let anyone else take your medication especially a woman who is or may become pregnant.

	How To Use Nitrogesic Use this ointment exactly as prescribed by your health care professional. Moreover, do not rub the Nitrogesic ointment onto the skin harshly. However, if you wish to use the medication for your children, please contact your pediatrician.

Nitrogesic side effects If you notice any of the symptoms, which seem severe or persistent to you, please contact your doctor immediately. The symptoms may be – blurred vision, headache, a feeling of extreme pressure in the head, sweating, nausea, vomiting, dry mouth, skin irritation from application of the ointment, flushing of the face or neck, palpitations i.e. irregular heartbeats, unusual weakness and tiredness, swelling on face, tongue, lips, skin hives, itching, rashes etc. Inform your doctor if you experience any of these side effects and if they appear too bothersome to you.

Nitrogesic interaction Inform your doctor if you are allergic to the formulation of this medication or any other medication in any other form and also inform your doctor about any other medication you may be taking in any other form. Nitrogesic may interact with the heparin, alteplase, foods, varied medications, aspirin medication for mental depression like phenothiazines, chlorpromazine, mesoridazine, prochlorperazine, thioridazine, medication for high blood pressure, medicines for treatment of erectile dysfunctions like Sildenafil, Tadalafil, and Vardenafil, certain migraine medicines like ergotamine or DHE, other medication used to treat angina etc. Hence, it is necessary to take proper precautions to avoid any reactions.

	Nitrogesic Over Dose In case of overdose call your local poison control center at 1-800-222-1222. If the suffering patient has collapsed or is not breathing call local emergency services at 911. Canadian residents should call their local poison control center directly.

Nitrogesic notes Do not allow any other person to use your medication without getting doctor’s prescription themselves and also avoid using this medicine for other health conditions on your own. It is essential to inform your doctor if you have or have ever had diseases like: liver disease, anemia, previous heart attack, bleeding in the brain, head injury, recent stroke etc. Avoid alcohol during the complete course. Keep the medicine away from the children and pets.

	Nitrogesic missed dose If you miss an application of this medicine, apply it as soon as you remember. And, if it is almost the time of your next application, skip the missed application and continue to your regular dosing. Do not double your applications in any case and consult your doctor for the missed application.

	Nitrogesic uses Ideally, Nitroglycerin ointment is used in the treatment for anal fissure as one can avoid surgery. However, Nitroglycerin relaxes the anal sphincter muscle and provides immediate symptomatic relief in pain and spasm. However, it may also be used to treat some other medical conditions which may be determined by your doctor accordingly.

	Nitrogesic other uses This medication may be prescribed for other uses also, so ask your doctor or pharmacist for more information about the Nitrogesic medication. Sometimes, the Nitrogesic ointment is used to treat chest pains.

	Nitrogesic storage Nitrogesic medication should be stored at 15-30°C and 59-86°F and at cool and dry place. Check Expiry date without fail. Keep all medicines away from women, newborns, children and pets. Also, keep it away from heat, dampness and direct light. In any case, do not store the Nitrogesic ointments in the bathroom.

Nitrogesic precaution Following precautions must be taken during consuming generic Nitrogesic: 1. It is very important for the patient to know that before using Nitrogesic they must inform their health care professional if you have or have ever had diseases like: liver disease, anemia, previous heart attack, bleeding in the brain, head injury, recent stroke etc. 2. Also acknowledge your doctor if you need to undergo any kind of surgery, including dental surgery or need an x-ray procedure that uses contrast agents. So, inform your doctor immediately about it, so that the doctor can decide whether to continue taking Nitrogesic or stop it during the surgery. 3. Let the doctor also know if you are in-taking or are planning to take any prescribed or non prescribed medicines, health supplements or any OTC medications, vitamins etc. 4. Do not use the Nitrogesic medication, if you have any kind of allergy to it or to any ingredients of it and tell your doctor or pharmacist about the allergy and get treated. 5. Tell your doctor if you are pregnant or breast feeding before taking Nitrogesic Cream medication or it may result in abortion. Hence, inform your doctor immediately when you plan to conceive, or become pregnant during the course. 6. Do not share the drug with others unless they are prescribed by the doctor themselves. And if your symptoms of side effects do not improve in few weeks or if they become worse and bothersome, check these conditions immediately with your doctor. 7. Please, use the medicine in the prescribed amount and do not overdose it or use it for the longer period of time. Do not discontinue on your own and consult your doctor before doing so to avoid further problems. 8. During the complete course, please avoid alcohol and alcohol containing beverages to achieve good results

Buying Medicine Online

These days, buying prescription drugs from the Internet is easy, but finding a safe source for those medicines is not. More and more people are turning to the Internet for cheaper drugs that are easy to get, but medicines purchased from these Web sites often come with the risk of harming you or your family. Rogue Web sites are all over the Internet selling drugs that are not what they appear to be. These sites may be selling drugs that are counterfeit, contaminated, or otherwise unsafe.
By being informed about the dangers of buying drugs on the Internet you can protect yourself and your family from the risks posed by rogue Web sites. NABP has been working with the state boards of pharmacy since 1999 to combat those sites that put your health and safety at risk. Over the years NABP has seen that the risks of buying from a rogue site don’t stop at the loss of money. Lives have been lost due to people buying medicines from sites that send dangerous drugs without medical oversight that may have been tampered with, expired, or even fake.
Knowing which Web sites are safe and which ones are not can be confusing. To help you make an informed choice, and as part of its mission to protect the public’s health, NABP has reviewed, and continues to review, thousands of Web sites to determine if they maintain safe pharmacy practices. Unfortunately, the majority of Web sites selling prescription drugs do not.
NABP has created two categories to help you make an informed choice:

• Recommended Internet Pharmacies: NABP recommends that patients use sites accredited through the VIPPS (Verified Internet Pharmacy Practice Sites) or Vet-VIPPS (Veterinary-Verified Internet Pharmacy Practice Sites) program. These sites have undergone and successfully completed the thorough NABP accreditation process, which includes a thorough review of all policies and procedures as well as an on-site inspection of all facilities used by the site to receive, review, and dispense medicine. 
• Not Recommended Sites: These Internet drug outlets appear to be out of compliance with state and federal laws or NABP patient safety and pharmacy practice standards.

Buyer Beware! That Web Site Might Not Be What It Seems

Many Web sites selling prescription drugs are unlicensed, operating illegally, or operating from foreign countries where medicines shipped to the United States are unregulated. Thus, there is no way of knowing whether the medicine you receive is contaminated, sub-potent, super-potent, expired, or counterfeit, or whether it has been stored and shipped under proper conditions to maintain its effectiveness.
And that Canadian online pharmacy with the cheaper prices? It may be calling itself a “Canadian pharmacy,” but it may actually obtain its medications from countries in Asia, South America, or Eastern Europe, where quality standards are more lax and counterfeit medications more widespread. While counterfeit medications can surface anywhere, they are significantly more common in developing foreign countries. That is the problem with buying medicine from foreign sources – you never know what you’re getting.
While there are some excellent Canadian Internet pharmacy sites, NABP cannot recommend any Canadian site selling drugs to Americans because Food and Drug Administration (FDA) regulations prohibit this activity. Prescription drugs imported from other countries are not FDA-approved and their safety and effectiveness cannot be ensured because they are outside the legal structure and regulatory resources provided by Congress.

What Are Sites Listed as Not Recommended Doing Wrong?

NABP continually reviews Web sites selling prescription drugs to help you see through rogue sites. Of the nearly 7,000 Internet sites reviewed, NABP found that 96% of the sites fall in the Not Recommended category because they appear to be operating in conflict with pharmacy laws and practice standards. Of the sites reviewed, the most common reasons for sites being included on the Not Recommended list were:

• 83% do not require a valid prescription
• 42% offer foreign or non-FDA-approved drugs
• 55% do not provide a physical address
• 20% are located outside of the United States and selling drugs illegally to patients in the US

Only 4% of the sites NABP reviewed are potentially legitimate in that they appear to meet pharmacy laws and practice standards, based on information obtained by looking at the Web site. NABP highly recommends that you use only those Internet pharmacies that are VIPPS or Vet-VIPPS accredited. Currently, 39 sites, representing more than 12,000 online pharmacies, have received accreditation.

Cancer, brain

Cancer, brain: Cancer of the central information processing center of the body. Tumors in the brain can be malignant or benign and can occur at any age. Primary brain tumors initially form in the brain tissue. Secondary brain tumors are cancers that have spread to the brain tissue (metastasized) from elsewhere in the body.